JBiolNMR
- Membrane protein structure determination from Paramagnetic Relaxation Enhancement and internuclear distance restraints
- COLMARvista: an open source 2D and pseudo-3D NMR spectral processing, visualization, and analysis software in JavaScript
- Quantifying protein-drug lifetimes in human cells by 19F NMR spectroscopy
- A complete set of cross-correlated relaxation experiments for determining the protein backbone dihedral angles
- Terminal spin labeling of xylotriose strongly affects interactions in the active site of xylanase BcX
- Improvement in protein HSQC spectra from addition of betaine
- Exploring the biochemical landscape of bacterial medium with pyruvate as the exclusive carbon source for NMR studies
- Counterintuitive method improves yields of isotopically labelled proteins expressed in flask-cultured Escherichia coli
- Local structure propensities in disordered proteins from cross-correlated NMR spin relaxation
- Reducing experimental time through spin-lattice relaxation enhancement via dissolved oxygen
- Solid state NMR spectral editing of histidine, arginine and lysine using Hadamard encoding
- 15N-detected TROSY for 1H-15N heteronuclear correlation to study intrinsically disordered proteins: strategies to increase spectral quality
- Evaluation of TOCSY mixing for sensitivity-enhancement in solid-state NMR and application of 4D experiments for side-chain assignments of the full-length 30 kDa membrane protein GlpG
- Alpha-helices as alignment reporters in residual dipolar coupling analysis of proteins
- Using temperature coefficients to support resonance assignment of intrinsically disordered proteins
Current opinion in structural biology
- Raman spectroscopy and imaging of protein droplet formation and aggregation
- Machine learning methods to study sequence–ensemble–function relationships in disordered proteins
- Protein folding by the CCT/TRiC chaperone complex
- Recent advances in AI-driven protein-ligand interaction predictions
- Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity
- Deciphering driving forces of biomolecular phase separation from simulations
- Dynamics-based drug discovery by time-resolved cryo-EM
- A structural perspective on enzymes and their catalytic mechanisms
- The “three body solution”: Structural insights into molecular glues
- Editorial overview: Catalysis and regulation (2024): Conformational dynamics of RNA and kinase signaling
- Traversing the drug discovery landscape using native mass spectrometry
- Chromatin domains in the cell: Phase separation and condensation
- Predicting the structure-altering mechanisms of disease variants
- Deep learning for RNA structure prediction
- A building blocks perspective on protein emergence and evolution
Protein Science
- Fine‐tuned interactions between globular and disordered regions of single‐stranded DNA binding (SSB) protein are required for dynamic condensation under physiological conditions
- Molecular mechanism of Mad2 conformational conversion promoted by the Mad2‐interaction motif of Cdc20
- Functional and structural characterization of Staphylococcus aureus N‐acetylglucosamine 1‐phosphate uridyltransferase (GlmU) reveals a redox‐sensitive acetyltransferase activity
- A suite of pre‐assembled, pET28b‐based Golden Gate vectors for efficient protein engineering and expression
- Tutorial on integrative spatiotemporal modeling by integrative modeling platform
- Deciphering opening mechanisms of 14‐3‐3 proteins
- Lysine carbamoylation during urea denaturation remodels the energy landscape of human transthyretin dissociation linked to unfolding
- AlphaFold2's training set powers its predictions of some fold‐switched conformations
- A new view of missense mutations in α‐mannosidosis using molecular dynamics conformational ensembles
- Comparison of enriched charge variants from different anti‐CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post‐translational modification
- Computational studies on the functional and structural impact of pathogenic mutations in enzymes
- Data‐driven evaluation of suitable immunogens for improved antibody selection
- SHARK‐capture identifies functional motifs in intrinsically disordered protein regions
- Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein‐binding zinc fingers
- Quantitative detection of amyloid fibrils using fluorescence resonance energy transfer between engineered yellow and cyan proteins
Structure
- Structure of the Staphylococcus aureus bacteriophage 80α neck shows details of the DNA, tail completion protein, and tape measure protein
- Disulfide-stabilized diabodies enable near-atomic cryo-EM imaging of small proteins: A case study of the bacterial Na+/citrate symporter CitS
- CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs
- The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore
- Structures of a T1-like siphophage reveal capsid stabilization mechanisms and high structural similarities with a myophage
- The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition
- Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET
- Structural basis for substrate binding, catalysis and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor
- Structural insights into polyisoprenyl-binding glycosyltransferases
- Structural variants of AcrIIC5 inhibit Cas9 via divergent binding interfaces
- Metal fluorides—multi-functional tools for the study of phosphoryl transfer enzymes, a practical guide
- The structure and assembly of the hetero-octameric BLOC-one-related complex
- Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation
- Physicochemical features of subunit interfaces and their role in self-assembly across the ferritin superfamily
- Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan
Biochemistry
JMB
- An RNA condensate model for the origin of life
- Cryo-EM reveals structural diversity in prolate-headed mycobacteriophage Mycofy1
- PERCEPTRON-XFMS: An Open-Source Web Server for Analysis of X-ray Footprinting with Mass Spectrometry Data
- GPx4 is bound to peroxidized membranes by a hydrophobic anchor
- The SinR•SlrR heteromer attenuates transcription of a long operon of flagellar genes in Bacillus subtilis
- Conformational and Functional Regulation of SET by Legumain Cleavage
- The Structure of the Drp1 Lattice on Membrane
- Deep mutational scanning of an engineered high-affinity ligand of the polyA binding protein MLLE domain
- Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
- Structural insight into the conversion of DhNik1, a hybrid histidine kinase from Debaryomyces hansenii to a cytotoxic phosphatase conformation for novel antifungal agent
- A simple method for generating light-induced clusters of transcription factors: effects on the nuclear distribution of OCT4 and on its interactions with chromatin
- Adaptive SELEX strategies against HCV core protein lead to the same aptamer
- Editorial Board
- Outside Front Cover
- Structural Impact of 3-methylcytosine Modification on the Anticodon Stem-loop of a Neuronally-enriched Arginine tRNA